THE TNFRH1 (TNFRSF23) GENE IS WEAKLY IMPRINTED IN SEVERAL ORGANS AND EXPRESSED AT THE TROPHOBLAST-DECIDUA INTERFACE

The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface

Abstract Background The Jackets Tnfrh1 gene (gene symbol Tnfrsf23) is located near one end of a megabase-scale imprinted region on mouse distal chromosome 7, about 350 kb distant from the nearest known imprinting control element.Within 20 kb of Tnfrh1 is a related gene called Tnfrh2 (Tnfrsf22) These duplicated genes encode putative decoy receptors

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Single cell lineage tracing reveals clonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer

Abstract Background Most primary Triple Negative Breast Cancers (TNBCs) show amplification of the Epidermal Growth Factor Receptor (EGFR) gene, leading to increased protein expression.However, unlike other EGFR-driven cancers, targeting this receptor in TNBC yields inconsistent therapeutic responses.Methods To elucidate the underlying mechanisms of

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Water bottle sign of pericardial effusion on chest radiograph

A 69-year-old lady diagnosed with congestive cardiac failure three Accessories years prior presented with worsening shortness of breath and bilateral leg swelling.She does not have a history of acute coronary syndrome, however an angiogram performed two years ago revealed a two-vessel disease.She also has hypothyroidism secondary to thyroidectomy.A

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